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secretase

Synonyms

Noun

1. enzyme

Usage
Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease - Nature
Glycemic variability associated with gamma secretase inhibitor therapy in a type 1 diabetic patient undergoing treatment for desmoid tumor: a case report - Frontiers
Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of γ-Secretase Activity - Journal of Neuroscience
Phase 2 GABriella Study Represents First Step in Testing Selective Novel Y-Secretase Modulators for Prodromal Alzheimer Disease - NeurologyLive
Alzheimer’s-in-a-Dish™: Developing Drugs for Disease Prevention and Treatment - Technology Networks
Molecular mechanism of substrate recognition and cleavage by human γ-secretase - Science | AAAS
Explainable AI helps decode the substrate specificity of γ-secretase enzyme - News-Medical
Charting γ-secretase substrates by explainable AI - Nature
Presenilin Loss Impairs Synaptic Transmission and Causes Axonal Degeneration through Ryanodine Receptor Dysfunction, Independent of γ-Secretase Activity - Journal of Neuroscience
Recognition of the amyloid precursor protein by human γ-secretase - Science | AAAS
Therapeutic effects of a novel synthetic α-secretase - Frontiers
Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform - Nature
Secretase promotes AD progression: simultaneously cleave Notch and APP - Frontiers
Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons - Journal of Neuroscience
Systemic Treatment with siRNA Targeting Gamma-Secretase Activating Protein Inhibits Amyloid-β Accumulation in Alzheimer’s Disease - Science Partner Journals
Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease - Frontiers
Defining the minimum substrate and charge recognition model of gamma-secretase - Nature
Structural basis of human γ-secretase inhibition by anticancer clinical compounds - Nature
Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein | Communications Biology - Nature
A thermodynamic investigation of amyloid precursor protein processing by human γ-secretase - Nature
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease - Nature
Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease - Nature
Structural basis of Notch recognition by human γ-secretase - Nature
An atomic structure of human γ-secretase - Nature
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease - Nature
EBP1 potentiates amyloid β pathology by regulating γ-secretase - Nature
γ-secretase inhibitors augment efficacy of BCMA-targeting bispecific antibodies against multiple myeloma cells without impairing T-cell activation and differentiation - Nature
Three-dimensional structure of human γ-secretase - Nature
Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling - Nature
Molecular pathogenesis of desmoid tumor and the role of γ-secretase inhibition - Nature
APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding - Nature
γ-secretase directly sheds the survival receptor BCMA from plasma cells - Nature
Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex - Nature
Gamma-secretase-dependent signaling of receptor tyrosine kinases - Oncogene - Nature
Role of cholesterol in substrate recognition by $$\gamma$$ -secretase | Scientific Reports - Nature
A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss - Nature
Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors - The New England Journal of Medicine
Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation - PNAS
Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate - PNAS
Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio - Nature
γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors - Frontiers
SERP1 is an assembly regulator of γ-secretase in metabolic stress conditions - Science | AAAS
Efficient production of a mature and functional gamma secretase protease - Nature
Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator - PNAS
Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis - Nature
TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production - Nature
η-Secretase processing of APP inhibits neuronal activity in the hippocampus - Nature
1999: Identifying the key enzyme β-secretase - Nature
BACE1 is the major β-secretase for generation of Aβ peptides by neurons - Nature
Substrate-targeting γ-secretase modulators - Nature
γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS) - The Lancet
Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site - Nature
A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease - The New England Journal of Medicine
The beta secretase BACE1 regulates the expression of insulin receptor in the liver - Nature
Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer’s disease hallmarks - Nature
GSAP modulates γ-secretase specificity by inducing conformational change in PS1 - PNAS
Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease - PNAS
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase - Nature
γ-Secretase Limits the Inflammatory Response Through the Processing of LRP1 - Science | AAAS
The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner - Nature
C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease - Nature
Royal jelly peptides: potential inhibitors of β-secretase in N2a/APP695swe cells - Nature
AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling - Nature
A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma - Nature
Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence - Nature
Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation - Nature
Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms - Frontiers
Cooperation of N- and C-terminal substrate transmembrane domain segments in intramembrane proteolysis by γ-secretase - Nature
Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion | Molecular Psychiatry - Nature
γ-Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of β-Carboxyl Terminal Fragment - Journal of Neuroscience
Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease - Nature
A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis | Cell Research - Nature
Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes - Nature
γ-Secretase Composed of PS1/Pen2/Aph1a Can Cleave Notch and Amyloid Precursor Protein in the Absence of Nicastrin - Journal of Neuroscience
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10 - PNAS
DNA damage-inducing agents elicit γ -secretase activation mediated by oxidative stress - Nature
Acute γ-Secretase Inhibition of Nonhuman Primate CNS Shifts Amyloid Precursor Protein (APP) Metabolism from Amyloid-β Production to Alternative APP Fragments without Amyloid-β Rebound - Journal of Neuroscience
Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10 - Nature
Microbial infection promotes amyloid pathology in a mouse model of Alzheimer’s disease via modulating γ-secretase - Nature
The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential - Journal of Neuroscience
γ-Secretase: proteasome of the membrane? - Nature
Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients - PNAS
Lowering of Amyloid-Beta by β-Secretase Inhibitors — Some Informative Failures - The New England Journal of Medicine
The γ-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus - PNAS
Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease - Neurology® Journals
γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase - Science | AAAS
TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer’s disease pathologies - Nature
Bax inhibitor 1 is a γ-secretase–independent presenilin-binding protein - PNAS
Influence of apolipoprotein E (apoE) on ADAM10 secretase in cerebrospinal fluid of older adults with Alzheimer’s disease - Wiley
Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production - Nature
Structural basis of human γ-secretase assembly - PNAS
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells - Nature
Sex-Specific Regulation of β-Secretase: A Novel Estrogen Response Element (ERE)-Dependent Mechanism in Alzheimer's Disease - Journal of Neuroscience
Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1 | Scientific Reports - Nature
Novel Social Stimulation Ameliorates Memory Deficit in Alzheimer's Disease Model through Activating α-Secretase - Journal of Neuroscience
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease - Nature
γ-Secretase inhibitors repress thymocyte development - PNAS
Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation - Nature
Targeting the β secretase BACE1 for Alzheimer's disease therapy - The Lancet
TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity - Nature
Foreign Language Equivalents
Foreign Language Equivalents of 'secretase'
Language Equivalent   Language Equivalent
French    Spanish
Misspellings - Typos
secrtase,   secreatse,   secrease,   secrtease,   ecretase,   secretaae,   secretaase,   scretase,   secretae,   secrwtase,   secretse,   secreyase,   seretase,   secretasee,   sevretase,   secrretase,   escretase,   secetase,   secertase,   sexretase,   secretsae,   secretas,   secrrtase,   secretade,   sercetase,   swcretase,   secretasr,   secretasse,   decretase,   seccretase,   secrerase,   ssecretase,   secretsse,   sectetase,   srcretase,   seecretase,   sceretase,   aecretase,   secretasw,   secretaes,   secrettase,   seceetase,   secreetase
Words Starting with Letter - 'A'
a a battery a billion
a bit a bit much a capella singing
a cappella singing a couple of a few
a fortiori a good deal a great deal
a horizon a hundred a hundred and one
a hundred thousand a hundred times a kempis
a la carte a la mode a level
a little a lot a million
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